Protein interaction AP-MS data for TAP-CSAG1 and TAP-CSAG2 from HEK293 cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Kidney
SUBMITTER: 
Patrick Potts
LAB HEAD: Patrick Ryan Potts
PROVIDER: PXD020231 | Pride | 2020-09-01
REPOSITORIES: Pride
Publications
CSAG2 is a cancer-specific activator of SIRT1.
Yang Xu X Potts Patrick Ryan PR
EMBO reports 20200805 9
SIRT1 is a NAD<sup>+</sup> -dependent deacetylase that controls key metabolic and signaling pathways, including inactivating the p53 tumor suppressor. However, the mechanisms controlling SIRT1 enzymatic activity in the context of cancer are unclear. Here, we show that the previously undescribed CSAG2 protein is a direct activator of SIRT1. CSAG2 is normally restricted to expression in the male germline but is frequently re-activated in cancers. CSAG2 is necessary for cancer cell proliferation an ...[more]
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