IFITM3 amino acid mutants phosphoproteomics

ABSTRACT: To investigate the role of IFITM3 in B-ALL, patient derived xenograft cells PDX2 were transduced with either a the constitutively membrane associated IFITM3-Y20E mutant or EV control. Additional mutation of PIP3 binding sites within the conserved internal loop region - K83/K104 or R85/R87/K88 - were introduced to test the predicted function of these sites.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Cell Culture

DISEASE(S): Acute Leukemia

SUBMITTER: Mark Robinson  

LAB HEAD: Markus Muschen

PROVIDER: PXD020696 | Pride | 2020-12-18

REPOSITORIES: Pride