Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Oral Cancer Cell
SUBMITTER: Kevin Klann
LAB HEAD: Christian Münch
PROVIDER: PXD021835 | Pride | 2022-06-23
REPOSITORIES: Pride
Delaunay Sylvain S Pascual Gloria G Feng Bohai B Klann Kevin K Behm Mikaela M Hotz-Wagenblatt Agnes A Richter Karsten K Zaoui Karim K Herpel Esther E Münch Christian C Dietmann Sabine S Hess Jochen J Benitah Salvador Aznar SA Frye Michaela M
Nature 20220629 7919
Aggressive and metastatic cancers show enhanced metabolic plasticity<sup>1</sup>, but the precise underlying mechanisms of this remain unclear. Here we show how two NOP2/Sun RNA methyltransferase 3 (NSUN3)-dependent RNA modifications-5-methylcytosine (m<sup>5</sup>C) and its derivative 5-formylcytosine (f<sup>5</sup>C) (refs.<sup>2-4</sup>)-drive the translation of mitochondrial mRNA to power metastasis. Translation of mitochondrially encoded subunits of the oxidative phosphorylation complex dep ...[more]