Dataset Information
Shingobium sp. strain Chol11 MALDI-TOF MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S): maXis
ORGANISM(S): Novosphingobium Sp. Chol11
SUBMITTER: 
Lars Wöhlbrand
LAB HEAD: Lars Wöhlbrand
PROVIDER: PXD022404 | Pride | 2021-04-21
REPOSITORIES: Pride
Publications
Substrate Inhibition of 5β-Δ<sup>4</sup>-3-Ketosteroid Dehydrogenase in <i>Sphingobium</i> sp. Strain Chol11 Acts as Circuit Breaker During Growth With Toxic Bile Salts.
Frontiers in microbiology 20210323
In contrast to many steroid hormones and cholesterol, mammalian bile salts are 5β-steroids, which leads to a bent structure of the steroid core. Bile salts are surface-active steroids excreted into the environment in large amounts, where they are subject to bacterial degradation. Bacterial steroid degradation is initiated by the oxidation of the A-ring leading to canonical Δ<sup>4</sup>-3-keto steroids with a double bond in the A-ring. For 5β-bile salts, this Δ<sup>4</sup>-double bond is introdu ...[more]
