The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer’s disease
Ontology highlight
ABSTRACT:
INSTRUMENT(S): TripleTOF 5600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
SUBMITTER: 
Frank Koopmans
LAB HEAD: Li, Ka Wan
PROVIDER: PXD023199 | Pride | 2021-09-09
REPOSITORIES: Pride
Publications
The proteome of granulovacuolar degeneration and neurofibrillary tangles in Alzheimer's disease.
Hondius David C DC Koopmans Frank F Leistner Conny C Pita-Illobre Débora D Peferoen-Baert Regina M RM Marbus Fenna F Paliukhovich Iryna I Li Ka Wan KW Rozemuller Annemieke J M AJM Hoozemans Jeroen J M JJM Smit August B AB
Acta neuropathologica 20210125 3
Granulovacuolar degeneration (GVD) is a common feature in Alzheimer's disease (AD). The occurrence of GVD is closely associated with that of neurofibrillary tangles (NFTs) and GVD is even considered to be a pre-NFT stage in the disease process of AD. Currently, the composition of GVD bodies, the mechanisms associated with GVD and how GVD exactly relates to NFTs is not well understood. By combining immunohistochemistry (IHC) and laser microdissection (LMD) we isolated neurons with GVD and those b ...[more]
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