Time-series proteomics and phosphoproteomics analysis of human airway epithelial cells in the absence or presence of a specific IKK inhibitor
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Lung, Epithelial Cell
SUBMITTER: 
Yingxin Zhao
LAB HEAD: Yingxin Zhao, Ph.D.
PROVIDER: PXD023531 | Pride | 2022-10-13
REPOSITORIES: Pride
Publications
Crosstalk of the IκB Kinase with Spliced X-Box Binding Protein 1 Couples Inflammation with Glucose Metabolic Reprogramming in Epithelial-Mesenchymal Transition.
Zhao Yingxin Y Zhang Jing J Sun Hong H Brasier Allan R AR
Journal of proteome research 20210614 7
Epithelial-mesenchymal transition (EMT) plays a critical role in airway injury, repair, and structural remodeling. IκB kinase (IKK)-NFκB signaling regulates late EMT-associated gene expression. However, IKK-mediated mesenchymal transition occurs earlier than NFκB/RelA subunit-dependent EMT gene expression, leading us to investigate the hypothesis that IKK plays an independent mechanism in transforming growth factor-β (TGFβ)-induced EMT. Time-resolved dissection of early proteome and phosphoprote ...[more]
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