Dataset Information

Minigut Cellular Proteome and Secretome

ABSTRACT: A mouse minigut Organoid model analysed using quantitative proteomics to measure proteins expressed in the crypt and villi –like cellular states, additionally providing novel details of the secreted proteins associated with these conditions.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Intestine, Stem Cell, Cell Culture

DISEASE(S): Celiac Disease

SUBMITTER: Robert Moulder

LAB HEAD: Riitta Lahesmaa

PROVIDER: PXD023737 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	161229_ENRC_1_SecVel3.raw	Raw
	161229_ENRC_2_SecVel3.raw	Raw
	161229_ENRC_NC_SecVel3.raw	Raw
	161229_ENRI_1_SecVel3.raw	Raw
	161229_ENRI_2_SecVel3.raw	Raw

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Publications

Comparative proteomics analysis of the mouse mini-gut organoid: insights into markers of gluten challenge from celiac disease intestinal biopsies.

Moulder Robert R Bhosale Santosh D SD Viiri Keijo K Lahesmaa Riitta R

Frontiers in molecular biosciences 20240828

<h4>Introduction</h4>Organoid models enable three-dimensional representation of cellular systems, providing flexible and accessible research tools, and can highlight key biomolecules. Such models of the intestinal epithelium can provide significant knowledge for the study of celiac disease and provide an additional context for the nature of markers observed from patient biopsy data.<h4>Methods</h4>Using LC-MS/MS, the proteomes of the crypt and enterocyte-like states of a mouse mini-gut organoid ...[more]

PMID: 39263374

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