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ITRAQ analysis of K562 cell line

ABSTRACT: K562 cells untreated (S) and treated (S+IM) with Imatinib as well as sensitive (S+IM) and resistant (R) to imatinib were subjected to labelled quantification by iTRAQ to identify Bcr-Abl downstream signaling components and proteins modulated in resistance respectively

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Suspension Culture

SUBMITTER: Mythreyi Narasimhan

LAB HEAD: Dr. Rukmini Govekar

PROVIDER: PXD025173 | Pride | 2021-10-05

REPOSITORIES: Pride

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Atypical activation of signaling downstream of inactivated Bcr-Abl mediates chemoresistance in chronic myeloid leukemia.

Narasimhan Mythreyi M Khamkar Vaishnavi V Tilwani Sarika S Dalal Sorab N SN Shetty Dhanlaxmi D Subramanian P G PG Gupta Sanjay S Govekar Rukmini R

Journal of cell communication and signaling 20211001 2

Chronic myeloid leukemia (CML) epitomises successful targeted therapy, where inhibition of tyrosine kinase activity of oncoprotein Bcr-Abl1 by imatinib, induces remission in 86% patients in initial chronic phase (CP). However, in acute phase of blast crisis, 80% patients show resistance, 40% among them despite inhibition of Bcr-Abl1 activity. This implies activation of either Bcr-Abl1- independent signalling pathways or restoration of signalling downstream of inactive Bcr-Abl1. In the present st ...[more]

PMID: 34596797

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