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Vitamin B12 stimulates 1,2-propanediol utilization in bacterial microcompartments of Listeria monocytogenes making anaerobic growth on rhamnose possible

ABSTRACT: This study was conducted in order to monitor whether or not Listeria monocytogenes is able to form bacterial microcompartment for rhamnose metabolism by deploying 1,2-propanediol bacterial microcompartment shell proteins and encapsulated enzymes.

INSTRUMENT(S): LTQ Orbitrap

ORGANISM(S): Listeria Monocytogenes Egd

SUBMITTER: Sjef Boeren

LAB HEAD: Sjef Boeren

PROVIDER: PXD025734 | Pride | 2021-06-21

REPOSITORIES: Pride

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Anaerobic Growth of <i>Listeria monocytogenes</i> on Rhamnose Is Stimulated by Vitamin B<sub>12</sub> and Bacterial Microcompartment-Dependent 1,2-Propanediol Utilization.

Zeng Zhe Z Li Siming S Boeren Sjef S Smid Eddy J EJ Notebaart Richard A RA Abee Tjakko T

mSphere 20210721 4

The foodborne pathogen Listeria monocytogenes can form proteinaceous organelles called bacterial microcompartments (BMCs) that optimize the utilization of substrates, such as 1,2-propanediol, and confer an anaerobic growth advantage. Rhamnose is a deoxyhexose sugar abundant in a range of environments, including the human intestine, and can be degraded in anaerobic conditions into 1,2-propanediol, next to acetate and lactate. Rhamnose-derived 1,2-propanediol was found to link with BMCs in some hu ...[more]

PMID: 34287006

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