Ontology highlight
ABSTRACT:
INSTRUMENT(S): impact II
ORGANISM(S): Rattus Norvegicus (rat)
TISSUE(S): Heart, Fibroblast
SUBMITTER: Andrew Bayne
LAB HEAD: Jean-Francois Trempe
PROVIDER: PXD025993 | Pride | 2023-05-10
REPOSITORIES: Pride
Khan Shahriar M SM Martin Ryan D RD Bayne Andrew A Pétrin Darlaine D Bourque Kyla K Jones-Tabah Jace J Bouazza Celia C Blaney Jacob J Lau Jenny J Martins-Cannavino Kimberly K Gora Sarah S Zhang Andy A MacKinnon Sarah S Trieu Phan P Clarke Paul B S PBS Trempe Jean-François JF Tanny Jason C JC Hébert Terence E TE
The Journal of biological chemistry 20230224 4
Gβγ subunits mediate many different signaling processes in various compartments of the cell, including the nucleus. To gain insight into the functions of nuclear Gβγ signaling, we investigated the functional role of Gβγ signaling in the regulation of GPCR-mediated gene expression in primary rat neonatal cardiac fibroblasts. We identified a novel, negative, regulatory role for the Gβ<sub>1</sub>γ dimer in the fibrotic response. Depletion of Gβ<sub>1</sub> led to derepression of the fibrotic respo ...[more]