Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): T Cell, Cell Culture
DISEASE(S): Disease Free
SUBMITTER: SoFong Cam Ngan
LAB HEAD: Navin Kumar Verma
PROVIDER: PXD026508 | Pride | 2022-02-17
REPOSITORIES: Pride
The Journal of biological chemistry 20211103 6
The steroidal lactone withaferin A (WFA) is a dietary phytochemical, derived from Withania somnifera. It exhibits a wide range of biological properties, including immunomodulatory, anti-inflammatory, antistress, and anticancer activities. Here we investigated the effect of WFA on T-cell motility, which is crucial for adaptive immune responses as well as autoimmune reactions. We found that WFA dose-dependently (within the concentration range of 0.3-1.25 μM) inhibited the ability of human T-cells ...[more]