Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Cell Culture, Macrophage
SUBMITTER: Jiradej Makjaroen
LAB HEAD: Asada Leelahavanichkul
PROVIDER: PXD027471 | Pride | 2022-02-22
REPOSITORIES: Pride
Thim-Uam Arthid A Makjaroen Jiradej J Issara-Amphorn Jiraphorn J Saisorn Wilasinee W Wannigama Dhammika Leshan DL Chancharoenthana Wiwat W Leelahavanichkul Asada A
International journal of molecular sciences 20220131 3
Because both endotoxemia and gut dysbiosis post-splenectomy might be associated with systemic infection, the susceptibility against infection was tested by dextran sulfate solution (DSS)-induced colitis and lipopolysaccharide (LPS) injection models in splenectomy mice with macrophage experiments. Here, splenectomy induced a gut barrier defect (FITC-dextran assay, endotoxemia, bacteria in mesenteric lymph nodes, and the loss of enterocyte tight junction) and gut dysbiosis (increased Proteobacteri ...[more]