Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Candida Glabrata (yeast) (torulopsis Glabrata)
SUBMITTER: Rupinder Kaur
LAB HEAD: Rupinder Kaur
PROVIDER: PXD029629 | Pride | 2022-04-04
REPOSITORIES: Pride
The Journal of biological chemistry 20220117 2
Invasive candidiasis poses a major healthcare threat. The human opportunistic fungal pathogen Candida glabrata, which causes mucosal and deep-seated infections, is armed with distinct virulence attributes, including a family of 11 glycosylphosphatidylinositol-linked aspartyl proteases, CgYapsins. Here, we have profiled total membrane proteomes of the C. glabrata wildtype and 11 proteases-deficient strain, Cgyps1-11Δ, by mass spectrometry analysis and uncovered a novel role for fungal yapsins in ...[more]