Mapping of nanobody binding sites on human LRRK2 by CX-MS

ABSTRACT: As part of an in-depth characterization of nanobodies directed against the human Leucine-rich repeat kinase 2 (LRRK2), epitopes of the nanobodies bound to LRRK2 were mapped by chemical crosslinking combined with mass spectrometry using the CID-cleavable crosslinker disuccinimidyl sulfoxide (DSSO).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Parkinson's Disease

SUBMITTER: Christian Johannes Gloeckner  

LAB HEAD: Christian Johannes Gloeckner

PROVIDER: PXD030063 | Pride | 2022-02-27

REPOSITORIES: Pride