Proteomics

Dataset Information

Regulation of cellular proteome and acetylome by catalytic and non-catalytic functions of class I histone deacetylases

ABSTRACT: Project description: Taking advantage of a newly generated model system, we examined the influence of class I HDAC catalytic and non-catalytic function on the cellular proteome and acetylome. Therefore, we generated HAP1 cell lines either lacking individual class I HDACs or expressing catalytically inactive isoforms. Using these cell lines, we investigated whether deletion or inactivation of specific class I HDACs better mimics inhibitor treated cells using isobaric labeling (TMTpro).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Haploid Cell

SUBMITTER: Markus Hartl  

LAB HEAD: Christian Seiser

PROVIDER: PXD030164 | Pride | 2022-08-16

REPOSITORIES: Pride

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20201005_QExHFX1_RSLC1_Hess_Seiser_ext_Uni_MFPL_insol_acetylome_rep1_pool1.raw Raw
20201005_QExHFX1_RSLC1_Hess_Seiser_ext_Uni_MFPL_insol_acetylome_rep1_pool2.raw Raw
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