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S100A4/TCF complex transcription regulation drives epithelial-mesenchymal transition in chronic sinusitis through Wnt/GSK-3β/β-catenin signaling

ABSTRACT: Chronic rhinosinusitis (CRS) is closely associated with remodelling of nasal mucosal tissue during a prolonged inflammatory process, and epithelial mesenchymal transition (EMT) is thought to be involved in this process, but the underlying mechanisms driving this progression are unclear. Using a high-resolution Q Exactive Plus Orbitrap mass spectrometer, we performed a proteomic screen of CRS nasal mucosal tissue to identify differentially expressed proteins.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Nasal Mucosa

SUBMITTER: Ningyue Gong

LAB HEAD: S100A4/TCF complex transcription regulation drives epithelial-mesenchymal transition in chronic sinusitis through Wnt/GSK-3β/β-catenin signaling

PROVIDER: PXD030884 | Pride | 2022-02-21

REPOSITORIES: Pride

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Publications

S100A4/TCF Complex Transcription Regulation Drives Epithelial-Mesenchymal Transition in Chronic Sinusitis Through Wnt/GSK-3β/β-Catenin Signaling.

Gong Ningyue N Shi Lei L Bing Xin X Li Hui H Hu Houyang H Zhang Pan P Yang Huiming H Guo Na N Du Hongjie H Xia Ming M Liu Chengcheng C

Frontiers in immunology 20220128

Epithelial-mesenchymal transition (EMT) is thought to be involved in the tissue remodeling and long-term inflammatory process of chronic sinusitis (CRS), but the driving mechanism is still unclear. Using high-resolution mass spectrometry, we performed a proteomic screen of CRS nasal mucosal tissue to identify differentially expressed proteins. Data are available <i>via</i> ProteomeXchange with identifier PXD030884. Specifically, we identified S100 calcium binding protein A4 (S100A4), an effectiv ...[more]

PMID: 35154161

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