Quantitative chemoproteomic identification of lysine carboxylation in proteins
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Escherichia Coli Synechocystis Sp.
SUBMITTER: 
Dustin King
LAB HEAD: David Vocadlo
PROVIDER: PXD031976 | Pride | 2023-09-09
REPOSITORIES: Pride
Publications
Chemoproteomic identification of CO<sub>2</sub>-dependent lysine carboxylation in proteins.
King Dustin T DT Zhu Sha S Hardie Darryl B DB Serrano-Negrón Jesús E JE Madden Zarina Z Kolappan Subramania S Vocadlo David J DJ
Nature chemical biology 20220616 7
Carbon dioxide is an omnipresent gas that drives adaptive responses within organisms from all domains of life. The molecular mechanisms by which proteins serve as sensors of CO<sub>2</sub> are, accordingly, of great interest. Because CO<sub>2</sub> is electrophilic, one way it can modulate protein biochemistry is by carboxylation of the amine group of lysine residues. However, the resulting CO<sub>2</sub>-carboxylated lysines spontaneously decompose, giving off CO<sub>2</sub>, which makes studyi ...[more]
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