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A TMT- based comparative quantitative proteomics analysis was used to reveal the changes of plasma proteomics profiles between longevity subjects and non-longevity area participants in order to identify plasma proteins associated with glucose metabolism in longevity population

ABSTRACT: High blood glucose level is one of the main characteristics of diabetes mellitus (DM). It is speculated that longevity families may have certain advantages in blood glucose regulation. But till now, limited information on these items is reported. In this study, a TMT- based comparative quantitative proteomics analysis was used to reveal the changes of plasma proteomics profiles between longevity subjects and non-longevity area participants in order to identify plasma proteins associated with glucose metabolism in longevity population and to explore the characteristics of blood glucose regulation in longevity population

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: shuang zheng

LAB HEAD: Rong Zhang

PROVIDER: PXD032932 | Pride | 2023-03-11

REPOSITORIES: Pride

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Proteomics profiles of blood glucose-related proteins involved in a Chinese longevity cohort.

Zhang Rong R Liu Fengjuan F Ye Shengliang S Du Xi X Ma Li L Cao Haijun H Wang Zongkui Z Li Changqing C

Clinical proteomics 20221203 1

<h4>Background</h4>High blood glucose level is one of the main characteristics of diabetes mellitus. Based on previous studies, it is speculated longevity families may have certain advantages in blood glucose regulation. However, limited information on these items has been reported. The purpose of this study was to profile differences of plasma proteomics between longevity subjects (with normal fructosamine (FUN) level) and non-longevity area participants (with exceeding standard FUN level).<h4> ...[more]

PMID: 36463101

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