Proteomics

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Profiling of purified autophagic vesicle content and degradome in the maturing and aging brain

ABSTRACT: In four label-free proteomics studies we characterize the organellar proteome of autophagosomes isolated from mouse brains using expression proteomics as well as organelle AP-MS.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

SUBMITTER: Joern Dengjel  

LAB HEAD: Joern Dengjel

PROVIDER: PXD034590 | Pride | 2023-08-07

REPOSITORIES: Pride

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202100606_DS_Col099A_AVWP__Aged_A__19.raw Raw
202100606_DS_Col099A_AVWP__Aged_A__20.raw Raw
202100606_DS_Col099A_AVWP__Aged_A__21.raw Raw
202100606_DS_Col099A_AVWP__Aged_B__22.raw Raw
202100606_DS_Col099A_AVWP__Aged_B__23.raw Raw
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Publications

Profiling of purified autophagic vesicle degradome in the maturing and aging brain.

Kallergi Emmanouela E   Siva Sankar Devanarayanan D   Matera Alessandro A   Kolaxi Angeliki A   Paolicelli Rosa Chiara RC   Dengjel Joern J   Nikoletopoulou Vassiliki V  

Neuron 20230605 15

Autophagy disorders prominently affect the brain, entailing neurodevelopmental and neurodegenerative phenotypes in adolescence or aging, respectively. Synaptic and behavioral deficits are largely recapitulated in mouse models with ablation of autophagy genes in brain cells. Yet, the nature and temporal dynamics of brain autophagic substrates remain insufficiently characterized. Here, we immunopurified LC3-positive autophagic vesicles (LC3-pAVs) from the mouse brain and proteomically profiled the  ...[more]

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