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Identification of novel SCF FBXW7 substrates in asynchronous and mitotic cells

ABSTRACT: FBXW7 loss-of-function has been implicated in chemoresistance against antimicrotubule drugs. FBXW7 is frequently mutated in human cancers and the identification of FBXW7 substrates, which could be involved in this phenotype, is a major task.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Simon Haenle-Kreidler

LAB HEAD: Ingrid Hoffmann

PROVIDER: PXD035501 | Pride | 2022-12-02

REPOSITORIES: Pride

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The SCF-FBXW7 E3 ubiquitin ligase triggers degradation of histone 3 lysine 4 methyltransferase complex component WDR5 to prevent mitotic slippage.

Hänle-Kreidler Simon S Richter Kai T KT Hoffmann Ingrid I

The Journal of biological chemistry 20221114 12

During prolonged mitotic arrest induced by antimicrotubule drugs, cell fate decision is determined by two alternative pathways, one leading to cell death and the other inducing premature escape from mitosis by mitotic slippage. FBWX7, a member of the F-box family of proteins and substrate-targeting subunit of the SKP1-CUL1-F-Box E3 ubiquitin ligase complex, promotes mitotic cell death and prevents mitotic slippage, but molecular details underlying these roles for FBWX7 are unclear. In this study ...[more]

PMID: 36395886

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