Dataset Information
Mass spectrometry analysis of proteins interacting with Fbxw7 in T cells
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): T Cell, Cell Culture
SUBMITTER: 
peihan wu
LAB HEAD: Zhijian Cai
PROVIDER: PXD057140 | Pride | 2025-04-16
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| MS2200453_PBS.mzid.gz | Mzid | |||
| MS2200453_PBS.mzid.gz_MS2200453_PBS.MGF | Mzid | |||
| MS2200453_PBS.raw | Raw | |||
| checksum.txt | Txt |
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Publications
Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation.
Immunity 20250410 6
Segmented filamentous bacteria are essential for intestinal T helper 17 (Th17) cell induction, but their colonization in the adult intestine is controversial. Therefore, whether there are gut microbiota (GMs) that mediate Th17 cell generation in humans of different ages is elusive. Here, we reported that colonization of ubiquitous Alcaligenes faecalis was sufficient to induce intestinal Th17 cells. Alcaligenes faecalis proteins were endocytosed by CD4<sup>+</sup> T cells in a manner dependent on ...[more]
