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Human Cardiovascular Tissue Extracellular Vesicles

ABSTRACT: Fewer than 50% of patients develop vascular and valvular calcification, implying differential pathogenesis. Tissue-entrapped extracellular vesicles (EVs) are found in mineralization but their contents and functions are unstudied. Tissue EVs were isolated from normal and diseased human carotid arteries and aortic valves by enzymatic digestion, serial (ultra)centrifugation and density-gradient separation.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human) Hathewaya Proteolytica Hathi

TISSUE(S): Carotid Artery, Aortic Valve, Carotid Atherosclerotic Plaque

SUBMITTER: Mark Blaser

LAB HEAD: Elena Aikawa

PROVIDER: PXD035529 | Pride | 2023-07-10

REPOSITORIES: Pride

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