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Utilising crosslinking MS to explore protein structure and interactions

ABSTRACT: In this study, we performed proteome-wide crosslinking mass spectrometry (XLMS) on human HEK293 intact organelles and examined the combined utility of these crosslinks with AlphaFold.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Jason Low

LAB HEAD: Jason Low

PROVIDER: PXD035844 | Pride | 2023-04-24

REPOSITORIES: Pride

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			Action	DRS
	20181108_Fusion_JL_exp1_CPF1.raw	Raw
	20181108_Fusion_JL_exp1_CPF10.raw	Raw
	20181108_Fusion_JL_exp1_CPF11.raw	Raw
	20181108_Fusion_JL_exp1_CPF12.raw	Raw
	20181108_Fusion_JL_exp1_CPF13.raw	Raw

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Publications

Paraneoplastic Erythema Nodosum as a Prelude to Hodgkin Lymphoma.

Samara Yazeed Y Thomas Justin J Dasanu Constantin A CA

Connecticut medicine 20170301 3

Erythema nodosum is currently thought to represent a delayed hypersensitivity reac- tion to deposition of circulating immune complexes, followed by neutrophilic infiltration of the septa in the subcutaneous tissue. We describe a patient with advanced Hodgkin lymphoma with B symptoms, preceded by erythema nodosum of the left shin by 12 weeks. This dermatologic entity cleared after the treatment for Hodgkin lymphoma, suggesting a true paraneoplastic reaction. Given its known temporal association w ...[more]

PMID: 29772158

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