Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Monocyte
SUBMITTER: Christopher Gerner
LAB HEAD: Christopher Gerner
PROVIDER: PXD036979 | Pride | 2023-07-20
REPOSITORIES: Pride
Fetahu Irfete S IS Esser-Skala Wolfgang W Dnyansagar Rohit R Sindelar Samuel S Rifatbegovic Fikret F Bileck Andrea A Skos Lukas L Bozsaky Eva E Lazic Daria D Shaw Lisa L Tötzl Marcus M Tarlungeanu Dora D Bernkopf Marie M Rados Magdalena M Weninger Wolfgang W Tomazou Eleni M EM Bock Christoph C Gerner Christopher C Ladenstein Ruth R Farlik Matthias M Fortelny Nikolaus N Taschner-Mandl Sabine S
Nature communications 20230626 1
Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profiling of BM aspirates from 11 subjects spanning three major NB subtypes and compare these to five age-matched and metastasis-free BM, followed by in-depth single cell analyses of tissue diversity and ce ...[more]