Proteomics

Dataset Information

0

Systematic comparative analysis of extracellular vesicles following apoptosis, necroptosis and ferroptosis


ABSTRACT: The formation of extracellular vesicles (EVs) has emerged as a novel paradigm in cell-to-cell communication during health and disease. According to the type of cell death modalities, the intercellular functions of EVs may be influenced by their biogenesis and composition. To identify a possible EV cargo signature, we performed a comparative analysis of steady-state (ssEVs) and cell death-associated EVs (cdEVs) following apoptosis (apoEVs), necroptosis (necEVs) and ferroptosis (ferEVs) in the same cell type. We determined the physical and biochemical characteristics, the protein cargo by mass spectrometry.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Sara Dufour  

LAB HEAD: Peter Vandenabeele

PROVIDER: PXD039297 | Pride | 2023-10-12

REPOSITORIES: Pride

altmetric image

Publications

Systematic compositional analysis of exosomal extracellular vesicles produced by cells undergoing apoptosis, necroptosis and ferroptosis.

Cappe Benjamin B   Vadi Mike M   Sack Eliza E   Wacheul Ludivine L   Verstraeten Bruno B   Dufour Sara S   Franck Julien J   Xie Wei W   Impens Francis F   Hendrix An A   Lafontaine Denis L J DLJ   Vandenabeele Peter P   Riquet Franck B FB  

Journal of extracellular vesicles 20231001 10


Formation of extracellular vesicles (EVs) has emerged as a novel paradigm in cell-to-cell communication in health and disease. EVs are notably produced during cell death but it had remained unclear whether different modalities of regulated cell death (RCD) influence the biogenesis and composition of EVs. To this end, we performed a comparative analysis of steady-state (ssEVs) and cell death-associated EVs (cdEVs) following TNF-induced necroptosis (necEVs), anti-Fas-induced apoptosis (apoEVs), an  ...[more]

Similar Datasets

2009-06-29 | E-GEOD-13299 | biostudies-arrayexpress
2023-01-13 | PXD038278 | Pride
2019-11-28 | PXD011513 | Pride
2010-05-19 | E-GEOD-16189 | biostudies-arrayexpress
2018-11-07 | PXD006115 | Pride
2020-01-31 | E-MTAB-8672 | biostudies-arrayexpress
2021-03-08 | PXD023848 | Pride
2024-01-26 | PXD041491 | Pride
2015-10-10 | E-MTAB-3951 | biostudies-arrayexpress
2019-12-09 | PXD013259 | Pride