Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Richard Scheltema
LAB HEAD: Richard Scheltema
PROVIDER: PXD039489 | Pride | 2024-02-05
REPOSITORIES: Pride
Bar Barroeta Awital A Albanese Pascal P Kadavá Tereza T Jankevics Andris A Marquart J Arnoud JA Meijers Joost C M JCM Scheltema Richard A RA
Journal of thrombosis and haemostasis : JTH 20240117 5
<h4>Background</h4>Factor (F)XI can be activated by proteases, including thrombin and FXIIa. The interactions of these enzymes with FXI are transient in nature and therefore difficult to study.<h4>Objectives</h4>To identify the binding interface between thrombin and FXI and understand the dynamics underlying FXI activation.<h4>Methods</h4>Crosslinking mass spectrometry was used to localize the binding interface of thrombin on FXI. Molecular dynamics simulations were applied to investigate confor ...[more]