Proteomics

Dataset Information

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The role of vagus nerve in liver physiology


ABSTRACT: Liver metabolism is highly dynamic and is regulated by nutrient availability and humoral factors. A growing body of evidence suggests that the autonomous central nervous system also plays an important role in coordinating hepatic metabolic functions, which confer the flexibility needed for adaptation to fed and fasting states. Because the vagus nerve is the major source of autonomic innervation to the gastrointestinal tract, including the liver, we investigated the role of gal innervation in the proteomic profile of the liver.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Thiago Verano-Braga  

LAB HEAD: Thiiago Verano Braga

PROVIDER: PXD041052 | Pride | 2025-05-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
QEHF2_07439_AL.raw Raw
QEHF2_07440_AL.raw Raw
QEHF2_07441_AL.raw Raw
QEHF2_07442_AL.raw Raw
QEHF2_07443_AL.raw Raw
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Publications


The liver serves as a major energetic reservoir for other tissues and its metabolic function is controlled by humoral and neural factors. The vagus nerve innervating the gastrointestinal tract plays an important role in regulating peripheral metabolism and energy expenditure. Although the liver receives vagus nerve fibers, the impact of this circuitry in the regulation of hepatic metabolism is still poorly understood. Herein, we used a combination of quantitative proteomics and in vivo imaging t  ...[more]

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