Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human) Viruses
TISSUE(S): B Cell, Blood
SUBMITTER: Michael Weekes
LAB HEAD: Michael Weekes
PROVIDER: PXD041336 | Pride | 2023-07-20
REPOSITORIES: Pride
Molecular cell 20230612 13
Epstein-Barr virus (EBV) causes infectious mononucleosis, triggers multiple sclerosis, and is associated with 200,000 cancers/year. EBV colonizes the human B cell compartment and periodically reactivates, inducing expression of 80 viral proteins. However, much remains unknown about how EBV remodels host cells and dismantles key antiviral responses. We therefore created a map of EBV-host and EBV-EBV interactions in B cells undergoing EBV replication, uncovering conserved herpesvirus versus EBV-sp ...[more]