Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human) Epstein-barr Virus Strain P3hr-1
TISSUE(S): B Cell, Blood
DISEASE(S): Lymphoma
SUBMITTER: Michael Weekes
LAB HEAD: Michael Weekes
PROVIDER: PXD013034 | Pride | 2019-06-28
REPOSITORIES: Pride
Wang Liang Wei LW Shen Hongying H Nobre Luis L Ersing Ina I Paulo Joao A JA Trudeau Stephen S Wang Zhonghao Z Smith Nicholas A NA Ma Yijie Y Reinstadler Bryn B Nomburg Jason J Sommermann Thomas T Cahir-McFarland Ellen E Gygi Steven P SP Mootha Vamsi K VK Weekes Michael P MP Gewurz Benjamin E BE
Cell metabolism 20190627 3
Epstein-Barr virus (EBV) causes Burkitt, Hodgkin, and post-transplant B cell lymphomas. How EBV remodels metabolic pathways to support rapid B cell outgrowth remains largely unknown. To gain insights, primary human B cells were profiled by tandem-mass-tag-based proteomics at rest and at nine time points after infection; >8,000 host and 29 viral proteins were quantified, revealing mitochondrial remodeling and induction of one-carbon (1C) metabolism. EBV-encoded EBNA2 and its target MYC were requi ...[more]