Proteomics

Dataset Information

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Plasma N-Glycoproteomics for BMI-discordant monozygotic twin pairs

ABSTRACT: The aim of the project was to identify altered plasma proteins and altered plasma N-glycopeptides from monozygotic twin pairs who are discordant for body weight. We performed targeted quantitative N-glycoproteomics from plasma samples from 48 twin pairs (n = 96 individuals).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Obesity,Type 2 Diabetes Mellitus

SUBMITTER: Sakari Joenväärä  

LAB HEAD: Risto Renkonen

PROVIDER: PXD041384 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

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Action DRS
20220117_P_SEC_PIETILAINEN_02B.raw.zip Raw
20220117_P_SEC_PIETILAINEN_03B.raw.zip Raw
20220117_P_SEC_PIETILAINEN_04B.raw.zip Raw
20220117_P_SEC_PIETILAINEN_05B.raw.zip Raw
20220117_P_SEC_PIETILAINEN_06B.raw.zip Raw
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Publications

Plasma N-Glycoproteomics in monozygotic twin pairs discordant for body mass index reveals an obesity signature related to inflammation and iron metabolism.

Muniandy Maheswary M   Joenväärä Sakari S   van der Kolk Birgitta W BW   Tohmola Tiialotta T   Haltia Hanna H   Saari Sina S   Hakkarainen Antti A   Lundbom Jesper J   Kuula Juho J   Groop Per-Henrik PH   Kaprio Jaakko J   Heinonen Sini S   Renkonen Risto R   Pietiläinen Kirsi H KH  

Biology direct 20250319 1

<h4>Background</h4>N-glycosylation is a complex, post-translational modification which influences protein function and is sensitive to physiological changes. Obesity is associated with alterations in protein function; however, little is known about the glycoproteome in obesity beyond observations of association with types and structures of selected glycopeptides. Most often, due to technical challenges, glycan composition and structure information are missing. Here, we combined label-free data-i  ...[more]

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