Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Manuela Pérez Berlanga
LAB HEAD: Magdalini Polymenidou
PROVIDER: PXD041795 | Pride | 2023-08-31
REPOSITORIES: Pride
Pérez-Berlanga Manuela M Wiersma Vera I VI Zbinden Aurélie A De Vos Laura L Wagner Ulrich U Foglieni Chiara C Mallona Izaskun I Betz Katharina M KM Cléry Antoine A Weber Julien J Guo Zhongning Z Rigort Ruben R de Rossi Pierre P Manglunia Ruchi R Tantardini Elena E Sahadevan Sonu S Stach Oliver O Hruska-Plochan Marian M Allain Frederic H-T FH Paganetti Paolo P Polymenidou Magdalini M
The EMBO journal 20230711 17
Aggregation of the RNA-binding protein TAR DNA-binding protein 43 (TDP-43) is the key neuropathological feature of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD). In physiological conditions, TDP-43 is predominantly nuclear, forms oligomers, and is contained in biomolecular condensates assembled by liquid-liquid phase separation (LLPS). In disease, TDP-43 forms cytoplasmic or intranuclear inclusions. How TDP-43 transitions f ...[more]