Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Ovis Aries
TISSUE(S): Lung, Epithelial Cell
DISEASE(S): Mixed Disorder As Reaction To Stress
SUBMITTER: david greening
LAB HEAD: David Greening & Prudence Pereira-Fantini
PROVIDER: PXD041917 | Pride | 2023-10-09
REPOSITORIES: Pride
Pereira-Fantini Prue M PM Kenna Kelly R KR Fatmous Monique M Sett Arun A Douglas Ellen E Dahm Sophia S Sourial Magdy M Fang Haoyun H Greening David W DW Tingay David G DG
American journal of physiology. Lung cellular and molecular physiology 20230920 5
Tidal ventilation is essential in supporting the transition to air-breathing at birth, but excessive tidal volume (V<sub>T</sub>) is an important factor in preterm lung injury. Few studies have assessed the impact of specific V<sub>T</sub> levels on injury development. Here, we used a lamb model of preterm birth to investigate the role of different levels of V<sub>T</sub> during positive pressure ventilation (PPV) in promoting aeration and initiating early lung injury pathways. V<sub>T</sub> was ...[more]