Dataset Information
Off-target profiling of several PARP inhibitors using immobilized Niraparib beads
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF-X, Orbitrap Exploris 480, Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Placenta, Hepg2 Cell, Hek-293 Cell, K-562 Cell, Cell Line Cell
SUBMITTER: 
Maria Faelth Savitski
LAB HEAD: Marcus Bantscheff
PROVIDER: PXD044330 | Pride | 2025-05-06
REPOSITORIES: Pride
Dataset's files
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Publications
Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation.
Cancer research communications 20240901 9
An in-depth multiomic molecular characterization of PARP inhibitors revealed a distinct poly-pharmacology of niraparib (Zejula) mediated by its interaction with lanosterol synthase (LSS), which is not observed with other PARP inhibitors. Niraparib, in a similar way to the LSS inhibitor Ro-48-8071, induced activation of the 24,25-epoxysterol shunt pathway, which is a regulatory signaling branch of the cholesterol biosynthesis pathway. Interestingly, the combination of an LSS inhibitor with a PARP ...[more]
