Proteomics

Dataset Information

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Expression proteomic profiling of Niraparib and Olaparib

ABSTRACT: Explore protein abundance changes in several cancer cell lines upon treatment with Niraparib or Olaparib

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Hcc-70 Cell, T-47d Cell, Uwb1.289 Cell, Uwb1.289+brca1 Cell, Mda-mb-231 Cell, Cell Line Cell

SUBMITTER: Maria Faelth Savitski  

LAB HEAD: Marcus Bantscheff

PROVIDER: PXD044333 | Pride | 2025-05-06

REPOSITORIES: Pride

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03230_F1_R1_P0264180B01_TMT10.raw.gz Raw
03230_F1_R1_P0264180B02_TMT10.raw.gz Raw
03230_F1_R1_P0264180B03_TMT10.raw.gz Raw
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Publications

An in-depth multiomic molecular characterization of PARP inhibitors revealed a distinct poly-pharmacology of niraparib (Zejula) mediated by its interaction with lanosterol synthase (LSS), which is not observed with other PARP inhibitors. Niraparib, in a similar way to the LSS inhibitor Ro-48-8071, induced activation of the 24,25-epoxysterol shunt pathway, which is a regulatory signaling branch of the cholesterol biosynthesis pathway. Interestingly, the combination of an LSS inhibitor with a PARP  ...[more]

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