Proteomics

Dataset Information

0

Live cell tracking of Niraparib off-targets using photo affinity labelling


ABSTRACT: Explore off-targets of Niraparib in live cells using photo affinity labelling (PAL)

INSTRUMENT(S): Orbitrap Fusion Lumos, Q Exactive HF-X, Orbitrap Exploris 480, Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): T-47d Cell, Cell Line Cell

SUBMITTER: Maria Faelth Savitski  

LAB HEAD: Marcus Bantscheff

PROVIDER: PXD044331 | Pride | 2025-05-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
07934_F1_R1_P0283070A01_TMT10.raw.gz Raw
07934_F1_R1_P0283080A01_TMT10.raw.gz Raw
F539560.dat Other
F539596.dat Other
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Publications


An in-depth multiomic molecular characterization of PARP inhibitors revealed a distinct poly-pharmacology of niraparib (Zejula) mediated by its interaction with lanosterol synthase (LSS), which is not observed with other PARP inhibitors. Niraparib, in a similar way to the LSS inhibitor Ro-48-8071, induced activation of the 24,25-epoxysterol shunt pathway, which is a regulatory signaling branch of the cholesterol biosynthesis pathway. Interestingly, the combination of an LSS inhibitor with a PARP  ...[more]

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