Proteomics

Dataset Information

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Proteomic analysis of MCL-1 interactors in liver

ABSTRACT: Mcl1-conditional mice were injected with AAV-LP1-Cre to delete endogenous MCL-1 and with AAV-LP1-Mcl1Flag (FLINT) or AAV-LP1-GFP (wt control). After 14 days, mitochondria were harvest from mouse livers and subjected to anti-FLAG immunoprecipitation. Immune complexes were subjected to LC MS/MS mass spectrometry. Two independent liver mitochondria immunoprecipitations were run in parallel.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Andy High  

LAB HEAD: Joseph T. Opferman

PROVIDER: PXD045111 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

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Action DRS
Opfergrp_030513_MclIP_WT1_band_01.raw Raw
Opfergrp_030513_MclIP_WT1_band_02.raw Raw
Opfergrp_030513_MclIP_WT1_band_03.raw Raw
Opfergrp_030513_MclIP_WT1_band_04.raw Raw
Opfergrp_030513_MclIP_WT1_band_05.raw Raw
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Publications

MCL-1 is essential for promoting the survival of many normal cell lineages and confers survival and chemoresistance in cancer. Beyond apoptosis regulation, MCL-1 has been linked to modulating mitochondrial metabolism, but the mechanism(s) by which it does so are unclear. Here, we show in tissues and cells that MCL-1 supports essential steps in long-chain (but not short-chain) fatty acid β-oxidation (FAO) through its binding to specific long-chain acyl-coenzyme A (CoA) synthetases of the ACSL fam  ...[more]

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