Proteomics

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Proteins that interact with WDR1 following gambogic amide treatment

ABSTRACT: Patient-derived glioma cells (PDCs) overexpressing WDR1 were treated with either gambogic amide or DMSO. Then, IP-MS analysis was applied to investigate the proteins that interacted with WDR1 in the two treatment groups.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Brain Cancer

SUBMITTER: Wei Han  

LAB HEAD: Wei Han

PROVIDER: PXD045343 | Pride | 2024-01-26

REPOSITORIES: Pride

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Publications

The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling.

Qu Jiaorong J   Qiu Bojun B   Zhang Yuxin Y   Hu Yan Y   Wang Zhixing Z   Guan Zhiang Z   Qin Yiming Y   Sui Tongtong T   Wu Fan F   Li Boyang B   Han Wei W   Peng Xiaozhong X  

Signal transduction and targeted therapy 20231108 1

Glioma is the most prevalent brain tumor, presenting with limited treatment options, while patients with malignant glioma and glioblastoma (GBM) have poor prognoses. The physical obstacle to drug delivery imposed by the blood‒brain barrier (BBB) and glioma stem cells (GSCs), which are widely recognized as crucial elements contributing to the unsatisfactory clinical outcomes. In this study, we found a small molecule, gambogic amide (GA-amide), exhibited the ability to effectively penetrate the bl  ...[more]

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