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Quantitative Proteome and Lysine Lactylome of Proteins in the Cortex of Sham and CCI Mouse

ABSTRACT: Quantitative proteome and lysine lactylome analyses were conducted on proteins extracted from the cortex of sham and controlled cortical impact (CCI) mice.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain, Neuron

DISEASE(S): Brain Disease

SUBMITTER: Weiji Weng

LAB HEAD: Junfeng Feng

PROVIDER: PXD045802 | Pride | 2026-03-02

REPOSITORIES: Pride

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			Action	DRS
	FE296LPLa_C1_Slot2-18_1_21461.zip	Other
	FE296LPLa_C2_Slot2-19_1_21463.zip	Other
	FE296LPLa_C3_Slot2-20_1_21465.zip	Other
	FE296LPLa_C4_Slot2-21_1_21467.zip	Other
	FE296LPLa_C5_Slot2-22_1_21469.zip	Other

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1 - 5 of 12

Publications

Tufm lactylation regulates neuronal apoptosis by modulating mitophagy in traumatic brain injury.

Weng Weiji W He Zhenghui Z Ma Zixuan Z Huang Jialin J Han Yuhan Y Feng Qiyuan Q Qi Wenlan W Peng Yidong Y Wang Jiangchang J Gu Jiacheng J Wang Wenye W Lin Yong Y Jiang Gan G Jiang Jiyao J Feng Junfeng J

Cell death and differentiation 20241105 3

Lactates accumulation following traumatic brain injury (TBI) is detrimental. However, whether lactylation is triggered and involved in the deterioration of TBI remains unknown. Here, we first report that Tufm lactylation pathway induces neuronal apoptosis in TBI. Lactylation is found significantly increased in brain tissues from patients with TBI and mice with controlled cortical impact (CCI), and in neuronal injury cell models. Tufm, a key factor in mitophagy, is screened and identified to be m ...[more]

PMID: 39496783

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Crotonylomics sequencing of human non small cell lung cancer cell lines

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