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Extracellular vesicles secreted from senescent cancer cells promote colorectal cancer progression through SERPINE1

ABSTRACT: By the iTRAQ-based quantitative proteomics, we assessed the protein cargos inside EVs secreted from colorectal cancer cells

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture, Colon

DISEASE(S): Colon Cancer

SUBMITTER: dan zhang

LAB HEAD: Fuxiang zhou

PROVIDER: PXD047062 | Pride | 2024-04-06

REPOSITORIES: Pride

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Publications

Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation.

Zhang Dan D Zhang Jian-Wei JW Xu Hui H Chen Xin X Gao Yu Y Jiang Huan-Gang HG Wang You Y Wu Han H Yang Lei L Wang Wen-Bo WB Dai Jing J Xia Ling L Peng Jin J Zhou Fu-Xiang FX

Molecular cancer 20240404 1

<h4>Background</h4>Cellular senescence frequently occurs during anti-cancer treatment, and persistent senescent tumor cells (STCs) unfavorably promote tumor progression through paracrine secretion of the senescence-associated secretory phenotype (SASP). Extracellular vesicles (EVs) have recently emerged as a novel component of the SASP and primarily mediate the tumor-promoting effect of the SASP. Of note, the potential effect of EVs released from STCs on tumor progression remains largely unknown ...[more]

PMID: 38576002

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