Dataset Information

Quantitative Proteomics of Dorsolateral Prefrontal Cortex

ABSTRACT: Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder with a rising prevalence and genetic and environmental etiologies. Symptoms include deficits in social communication, repetitive patterns of behavior, and cognitive impairment. Neuroanatomic and biochemical investigations involve many brain areas with imbalance between glutamatergic and inhibitory neurotransmitters. We hypothesized that investigation of the synaptic compartment of the dorsolateral prefrontal cortex may provide proteomics signatures that may identify the biological underpinnings of cognitive deficits in childhood ASD. Subcellular fractionation of the synaptoneurosomes from Brodmann area 9 of a well- characterized age- and postmortem-interval-matched samples from children and adults with idiopathic ASD vs. healthy controls, were subjected to HPLC–tandem mass spectrometry and proteomic analysis.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cerebral Cortex Neuron, Brain

DISEASE(S): Autism Spectrum Disorder

SUBMITTER: Arthur Eschenlauer

LAB HEAD: S.Hossein Fatemi

PROVIDER: PXD048017 | Pride | 2025-05-06

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	fatem002_18100_20210622_BA9-Child.mzML	Mzml
	fatem002_18100_20210622_BA9-Child.mzid.gz	Mzid
	fatem002_18100_20210622_BA9-Child_F10.raw	Raw
	fatem002_18100_20210622_BA9-Child_F11.raw	Raw
	fatem002_18100_20210622_BA9-Child_F12.raw	Raw

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Publications

Quantitative proteomics of dorsolateral prefrontal cortex reveals an early pattern of synaptic dysmaturation in children with idiopathic autism.

Fatemi S Hossein SH Eschenlauer Arthur A Aman Justin J Folsom Timothy D TD Chekouo Thierry T

Cerebral cortex (New York, N.Y. : 1991) 20240501 13

Autism spectrum disorder (ASD) is a developmental disorder with a rising prevalence and unknown etiology presenting with deficits in cognition and abnormal behavior. We hypothesized that the investigation of the synaptic component of prefrontal cortex may provide proteomic signatures that may identify the biological underpinnings of cognitive deficits in childhood ASD. Subcellular fractions of synaptosomes from prefrontal cortices of age-, brain area-, and postmortem-interval-matched samples fro ...[more]

PMID: 38696595

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