Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Spleen, Pancreas
SUBMITTER: Edward Cruz
LAB HEAD: Martin Wuhr
PROVIDER: PXD048041 | Pride | 2024-04-25
REPOSITORIES: Pride
Shen Yihui Y Dinh Hoang V HV Cruz Edward R ER Chen Zihong Z Bartman Caroline R CR Xiao Tianxia T Call Catherine M CM Ryseck Rolf-Peter RP Pratas Jimmy J Weilandt Daniel D Baron Heide H Subramanian Arjuna A Fatma Zia Z Wu Zong-Yen ZY Dwaraknath Sudharsan S Hendry John I JI Tran Vinh G VG Yang Lifeng L Yoshikuni Yasuo Y Zhao Huimin H Maranas Costas D CD Wühr Martin M Rabinowitz Joshua D JD
Nature chemical biology 20240306
Metabolic efficiency profoundly influences organismal fitness. Nonphotosynthetic organisms, from yeast to mammals, derive usable energy primarily through glycolysis and respiration. Although respiration is more energy efficient, some cells favor glycolysis even when oxygen is available (aerobic glycolysis, Warburg effect). A leading explanation is that glycolysis is more efficient in terms of ATP production per unit mass of protein (that is, faster). Through quantitative flux analysis and proteo ...[more]