Proteomics

Dataset Information

0

Proteomic and Metabolomic Profile of Cognitive Stability and Decline Over an Aerobic Exercise Intervention and 5-years later in Older Adults

ABSTRACT: . In this study we identify a unique signature protein and metabolic biomarker panel for those who improve in cognition and those who decline, assessed by the Montreal Cognitive Assessment (MoCA). We investigate a discovery cohort of Brain in Motion participants involving a quasi-experimental aerobic exercise intervention study and analyze blood plasma before and after a six-month aerobic exercise intervention and 5 years later. We relate the differentially expressed proteins and metabolites to subjective sleep quality measures and fitness level. This study informs on the differences in the plasma of those who decline and those who improve in cognition, identifying pathways that are of importance for preventing cognitive decline.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Luiz Gustavo de Almeida  

LAB HEAD: Antoine Dufour

PROVIDER: PXD049430 | Pride | 2025-04-15

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
S10940_Marc_5_269_201020.raw Raw
S10941_Marc_6_270_201020.raw Raw
S10942_Marc_9_273_201020.raw Raw
S10943_Marc_10_274_201020.raw Raw
S10944_Marc_11_275_201020.raw Raw
Items per page:
1 - 5 of 73
altmetric image

Publications

The physiological basis of cognitive decline remains largely uncharacterized. We identified a protein panel signature, in living humans, that correlates to improvement in neurocognition over a period of 5 years. Our signature is composed of complement proteins, coagulation cascade, and extracellular matrix regulators. In our cohort, SERPINF1 is associated with greater maximal oxygen uptake after an aerobic exercise intervention. Sleep quality is also a key factor in relation to inter-alpha-tryps  ...[more]

Similar Datasets

Transcriptomics High intensity aerobic exercise suppresses cancer growth by regulating skeletal muscle-derived oncogenes and tumor suppressors (Lung)
2022-07-13 | GSE191284 | GEO
Transcriptomics High intensity aerobic exercise suppresses cancer growth by regulating skeletal muscle-derived oncogenes and tumor suppressors (Heart)
2022-07-13 | GSE191283 | GEO
Transcriptomics High intensity aerobic exercise suppresses cancer growth by regulating skeletal muscle-derived oncogenes and tumor suppressors (Gastrocnemius)
2022-07-13 | GSE191281 | GEO
Transcriptomics Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks
2014-05-23 | E-GEOD-57880 | biostudies-arrayexpress
Genomics Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks
2014-05-23 | GSE57880 | GEO
Transcriptomics Cardiac and Soleus muscles following exposure of rats to heat acclimation and exercise training
2010-05-27 | E-GEOD-7799 | biostudies-arrayexpress
Transcriptomics Role of aerobic exercise in ameliorating NASH
2023-01-11 | GSE217155 | GEO
Proteomics Liquid chromatography-tandem mass spectrometry analysis of bone marrow from the ground or running rats
2023-10-17 | PXD033807 | Pride
Transcriptomics Contractile activity-specific transcriptome response to acute endurance exercise and training in human skeletal muscle
2019-02-16 | GSE120862 | GEO
Transcriptomics High and low exercise responders
2012-01-01 | GSE20997 | GEO