Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Plasma Cell, Bone Marrow
DISEASE(S): Multiple Myeloma
SUBMITTER: Lama Hasan Bou Issa
LAB HEAD: Salomon Manier
PROVIDER: PXD050010 | Pride | 2024-04-09
REPOSITORIES: Pride
Hasan Bou Issa Lama L Fléchon Léa L Laine William W Ouelkdite Aicha A Gaggero Silvia S Cozzani Adeline A Tilmont Remi R Chauvet Paul P Gower Nicolas N Sklavenitis-Pistofidis Romanos R Brinster Carine C Thuru Xavier X Touil Yasmine Y Quesnel Bruno B Mitra Suman S Ghobrial Irene M IM Kluza Jérôme J Manier Salomon S
iScience 20240304 4
Multiple myeloma (MM) is an incurable hematological malignancy in which MYC alterations contribute to the malignant phenotype. Nevertheless, MYC lacks therapeutic druggability. Here, we leveraged large-scale loss-of-function screens and conducted a small molecule screen to identify genes and pathways with enhanced essentiality correlated with <i>MYC</i> expression. We reported a specific gene dependency in glutaminase (GLS1), essential for the viability and proliferation of MYC overexpressing ce ...[more]