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Huamn iPSC midbrain neuron Parkinson disease

ABSTRACT: Proteomic analysis of iPSC-midbrain neuron cultures from Parkinson's disease patients haboring A53T pathogenic variant

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Midbrain Dopaminergic Neuron Differentiation, Cell Culture

DISEASE(S): Parkinson's Disease

SUBMITTER: Joseph Mazzulli

LAB HEAD: Joseph Mazzulli

PROVIDER: PXD051673 | Pride | 2025-08-25

REPOSITORIES: Pride

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			Action	DRS
	20180420_vcs075_18-1234_Mazzulli_Nandkishore_S1.raw	Raw
	20180420_vcs075_18-1234_Mazzulli_Nandkishore_S2.raw	Raw
	20180420_vcs075_18-1234_Mazzulli_Nandkishore_S3.raw	Raw
	20180420_vcs075_18-1234_Mazzulli_Nandkishore_S4.raw	Raw
	20180420_vcs075_18-1234_Mazzulli_Nandkishore_T1.raw	Raw

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Publications

Nuclear aggregates of NONO/SFPQ and A-to-I-edited RNA in Parkinson's disease and dementia with Lewy bodies.

Belur Nandkishore R NR Bustos Bernabe I BI Lubbe Steven J SJ Mazzulli Joseph R JR

Neuron 20240517 15

Neurodegenerative diseases are commonly classified as proteinopathies that are defined by the aggregation of a specific protein. Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are classified as synucleinopathies since α-synuclein (α-syn)-containing inclusions histopathologically define these diseases. Unbiased biochemical analysis of PD and DLB patient material unexpectedly revealed novel pathological inclusions in the nucleus comprising adenosine-to-inosine (A-to-I)-edited mRNAs a ...[more]

PMID: 38761794

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