Dataset Information
TurboID of EWS-FLI1 and EWS-P3 fusion proteins
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Erik Soderblom
LAB HEAD: Christopher Counter
PROVIDER: PXD051746 | Pride | 2026-03-26
REPOSITORIES: Pride
Dataset's files
Items per page: 1 - 5 of 17 |
Publications
Fusion-positive rhabdomyosarcoma oncofusions share a common interactome.
Nature communications 20260528 1
Fusion-positive rhabdomyosarcoma (FP-RMS) arises from at least seven distinct oncofusions sharing a common PAX3/7 N-terminal DNA-binding domain fused to divergent C-terminal partners. How different oncofusions produce the same cancer was unknown. Here we show they are functionally interchangeable, associate with a shared protein network we term the common interactome, bind overlapping target genes, and drive a similar core transcriptional program. The common interactome contains the C-terminal p ...[more]