Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Skeletal Muscle Myoblast, Skeletal Muscle Cell
DISEASE(S): Disease Free
SUBMITTER: Julian Bender
LAB HEAD: Bettina Warscheid
PROVIDER: PXD053234 | Pride | 2025-05-07
REPOSITORIES: Pride
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Scientific reports 20241109 1
The actin-binding protein filamin c (FLNc) is a key mediator in the response of skeletal muscle cells to mechanical stress. In addition to its function as a structural scaffold, FLNc acts as a signaling adaptor which is phosphorylated at S2234 in its mechanosensitive domain 20 (d20) through AKT. Here, we discovered a strong dephosphorylation of FLNc-pS2234 in cultured skeletal myotubes under acute mechanical stress, despite high AKT activity. We found that all three protein phosphatase 1 (PP1) i ...[more]