Proteomics

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Proteomic analysis of Lineage negative bone marrow cells from wild-type and Dcaf8 knockout mice

ABSTRACT: To explore the mechanisms by which DCAF8 deficiency induces functional defects in hematopoietic stem cells with an aging-like phenotype, and given DCAF8’s role as a substrate receptor in the E3 ubiquitin ligase complex, we conducted proteomic analysis on Lineage negative bone marrow cells from wild-type and Dcaf8 knockout mice. This analysis aimed to identify protein alterations, providing insights into potential substrates of DCAF8 in murine hematopoietic cells.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Bone Marrow

SUBMITTER: Pengfei Xu  

LAB HEAD: Ping Liu

PROVIDER: PXD056107 | Pride | 2025-10-04

REPOSITORIES: Pride

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Publications

Loss of DCAF8 impairs hematopoietic stem cell function with cellular senescence via the DOCK11-CDC42 axis.

Xu Pengfei P   Zhang Xiuli X   Li Donghe D   Jiao Bo B   Nie Jiawei J   Huang Yi Y   Xia Zhizhou Z   Li Jiaoyang J   Dan Yuqing Y   Huang Xu X   Yan Lei L   Zhang Rui R   Huang Wei W   Wang Xinru X   Ji Shiyu S   Cang Yong Y   Ren Ruibao R   Liu Ping P  

Blood 20250901 12

<h4>Abstract</h4>Hematopoietic stem cells (HSCs) are responsible for sustaining the hematopoietic system throughout life, and their functional decline contributes to hematological disorders and organismal aging. Understanding the molecular mechanisms that govern HSC function is critical for developing interventions for treating and preventing aging-related diseases. Here, we show that DCAF8, a substrate recognition component of Cullin-RING E3 ubiquitin ligases, is highly expressed in HSCs and un  ...[more]

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