Cell-specific proteome analyses of human bone marrow upon aging.

ABSTRACT: Diminishing potential to replace damaged tissues is a hallmark for aging of somatic stem cells, but the mechanisms leading to aging remain elusive. We performed a proteome-wide analysis of human hematopoietic stem and progenitor cells (CD34+) along with five other cell types that constitute the bone marrow niche, namely, lymphocytes and precursors; monocytes/macrophages and precursors; granulocytic precursors and erythroid precursors, as well as mesenchymal stem/stromal cells. In total, we analyzed 270 samples from 59 human subjects. The data represents a valuable resource for further in-depth mechanistic analyses, and for validation of knowledge gained from animal models.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Mesenchymal Stem Cell, Bone Marrow Stromal Stem Cell, Haematopoietic Stem Cells

SUBMITTER: Marco L. Hennrich  

LAB HEAD: Anne-Claude Gavin

PROVIDER: PXD007048 | Pride | 2018-07-20

REPOSITORIES: Pride