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Paleoproteomic analysis of dental pulp proteins from camel teeth

ABSTRACT: Paleoproteomic analysis was carried out on dental pulp proteins from camel teeth with the objective of identification of the death causal agent. Interpretation of the data was performed with a database constructed with preliminary information.

INSTRUMENT(S):

ORGANISM(S): Yersinia Pestis Yersinia Pseudotuberculosis Camelus Dromedarius (dromedary) (arabian Camel)

TISSUE(S): Dental Pulp

SUBMITTER: Jean ARMENGAUD

LAB HEAD: Jean Armengaud

PROVIDER: PXD056179 | Pride | 2025-09-15

REPOSITORIES: Pride

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			Action	DRS
	E06740_MS24-028_blanc.mgf	Mgf
	E06740_MS24-028_blanc.raw	Raw
	E06744_MS24-028_RO1.mgf	Mgf
	E06744_MS24-028_RO1.raw	Raw
	E06745_MS24-028_RO2.mgf	Mgf

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Publications

Diagnosing plague in 17th century camelids from Romania along historical Silk Routes.

Oumarou Hama Hamadou H Boualam Mahmoud M Armengaud Jean J Drancourt Michel M Aboudharam Gérard G Bălășescu Adrian A Radu Valentin V

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 20250822

Six camels exhumed from a 17th-century Silk Route site in Romania, along with negative controls, were blindly investigated via dental pulp paleometagenomics and paleoproteomics for traces of Yersinia pseudotuberculosis complex including the plague agent Yersinia pestis. Specific reads were detected in sample R04 (one read) and R05 (two reads) which also yielded a 16S rRNA guanine transferase specific for Y. pestis and one other Y. pseudotuberculosis complex peptide. Taken together, these validat ...[more]

PMID: 40850381

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Project description:To identify and compare protein profiles of supernumerary dental pulp tissue and normal dental pulp tissue. Dental pulp tissues were obtained from supernumerary and permanent teeth. Proteins were extracted and analyzed by Liquid Chromatography-Tandem Mass Spectrometry (LC/MS-MS). MS data were elaborated with MaxQuant for protein identification and quantification. The statistical analysis was conducted using Metaboanalyst software. Differentially expressed proteins (DEPs) were determined (P-value<0.05, FC>2).

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