Proteomics

Dataset Information

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BCMA ubiquitylation in multiple myeloma

ABSTRACT: Mass spectrometric analysis of MM cell-purified B-cell maturation antigen (BCMA) protein to identify ubiquitylation sites.

INSTRUMENT(S): Orbitrap Exploris 480

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

DISEASE(S): Multiple Myeloma

SUBMITTER: Piero Giansanti  

LAB HEAD: Piero Giansanti

PROVIDER: PXD056372 | Pride | 2025-07-29

REPOSITORIES: Pride

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Dataset's files

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Exp1_0390_R0050-08_S006708_G_B01_LFQ_01.raw Raw
Exp1_0390_R0050-08_S006708_G_B02_LFQ_01.raw Raw
Exp1_0390_R0050-08_S006708_G_B03_LFQ_01.raw Raw
Exp1_0390_R0050-08_S006708_G_B04_LFQ_01.raw Raw
Exp1_0390_R0050-08_S006708_G_B05_LFQ_01.raw Raw
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Publications

Boosting CAR T-Cell Efficacy by Blocking Proteasomal Degradation of Membrane Antigens.

Rieger Leonie L   Irlinger Kilian K   Füchsl Franziska F   Tietje Marlene M   Purcarea Anna A   Barbian Nicolas Mathis NM   Faber Melanie M   Vogelsang Carolin C   Pfeuffer Lisa L   Stotz Sonja S   Karpiuk Oleksandra O   Schulze Tobias T   Augsburger Abirami A   Glaisner Nadine N   Konetzki Verena V   Friedel Sabrina S   Besse Andrej A   Besse Lenka L   Driessen Christoph C   Buchner Maike M   Schwamborn Kristina K   Steiger Katja K   Giansanti Piero P   Theurich Sebastian S   Waldschmidt Johannes M JM   Kortüm Klaus Martin KM   Hudecek Michael M   Einsele Hermann H   Högner Marion M   Kuster Bernhard B   Krackhardt Angela A   Hecker Judith S JS   Bassermann Florian F  

Blood 20250710

Chimeric antigen receptor (CAR) T cells exhibit high response rates in B cell malignancies, but most patients eventually relapse. A key mechanism of treatment failure is the loss or downregulation of tumor antigen expression, yet strategies to modulate cell surface levels of CAR T cell targets remain largely unexplored. Here we identify B cell maturation antigen (BCMA), a central CAR T cell target in multiple myeloma (MM), as a highly short-lived protein that undergoes K48-linked polyubiquitylat  ...[more]

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