Dataset Information
BCMA ubiquitylation in multiple myeloma
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Multiple Myeloma
SUBMITTER: 
Piero Giansanti
LAB HEAD: Piero Giansanti
PROVIDER: PXD056372 | Pride | 2025-07-29
REPOSITORIES: Pride
Dataset's files
Items per page: 1 - 5 of 18 |
Publications
Boosting CAR T-cell efficacy by blocking proteasomal degradation of membrane antigens.
Blood 20260101 5
<h4>Abstract</h4>Chimeric antigen receptor (CAR) T cells exhibit high response rates in B-cell malignancies, but most patients eventually relapse. A key mechanism of treatment failure is the loss or downregulation of tumor antigen expression, yet strategies to modulate cell surface levels of CAR T-cell targets remain largely unexplored. Here, we identify B-cell maturation antigen (BCMA), a central CAR T-cell target in multiple myeloma (MM), as a highly short-lived protein that undergoes K48-link ...[more]